In sheep and goats the lesions mostly appear on or near the hairline and elsewhere on the lips and muzzle. In some cases the lesions appear on and in the nostrils, around the eyes, on the thigh, coronet, vulva, udder and axilla. In rare cases, mostly involving young lambs, lesions are found on the tongue, gums, roof of the mouth and the oesophagus. It has also been reported a number of times to cause lesions in the rumen. In one case it was shown that a severe form of orf virus caused an outbreak involving the gastrointestinal tract, lungs, heart, as well as the buccal cavity, cheeks, tongue and lips. Another severe case was reported pharyngitis, genital lesions and infection of the hooves which led to lameness and, in some cases, sloughing of the hoof. 
bfhu: First, reread all 33 posts in this series. What I can recall: Collagen is a major constituent of the endothelium, and both the amino acid glycine (rich in the skin, bones and connective tissue of the animals we eat) and vitamin C are critical for its formation. Thus, drink bone broth and take vitamin C. Also, vitamin E plays a role in endothelial health, particularly the d-tocotreinol form (best sources red palm oil and annatto seeds). NO is crucial, so get out in the sun, and do activities which raise your pulse at least 10-15 bpm on a daily basis. Also of great importance: Worry not, not the little things, not the big things (easy for us to do who are well-fed and live in developed countries).
Physical fitness is a measure of the condition of the body to perform during activities of daily living (light, moderate, and strenuous), formal exercise (like when you work out), and emergencies (as when you must escape from danger like a fire). The physical fitness of our nation is declining, proved by the rising rates of obesity , diabetes , some types of cardiovascular disease, and other medical conditions. To improve physical fitness, one must "practice," or work out. Emphasis should be on improving aerobic conditioning (stamina or endurance), muscular strength and endurance, and flexibility. The types of exercise necessary to do this are described next.